Trans-splicing, the possibility of exons from distinct pre-mRNAs to join together, is still a concept in gene expression that is Spacecraft Model Kit generally regarded of limited significance.However, recent work has provided evidence that in human tumors trans-splicing events may precede chromosomal rearrangements.In fact, it has been suggested Wooden Figure that the trans-spliced molecules could act as guides that facilitate the genomic translocation.This perspective highlights the development of the ideas of trans-splicing in higher eukaryotes during the last twenty five years, from a bizarre phenomenon to a biological event that is attaining stronger recognition.